Last revised December 4, 2017 1. Which psychiatric medications can cause hyponatremia? Oxcarbazepine, carbamazepine, and serotonergic antidepressants are the psychotropic medications most commonly associated with hyponatremia due syndrome of inappropriate antidiuretic hormone secretion (SIADH). Several other medications may also be associated with hyponatremia at times, including other antiepileptics like valproate (Beers et al., 2010) and…