Note: In our opinion, only practice guidelines published in the last ten years should be considered by clinicians. Practice guidelines published earlier than that should be assumed to be obsolete.
American College of Physicians
Qaseem A, Barry MJ, Kansagara D; Clinical Guidelines Committee of the American College of Physicians. Nonpharmacologic Versus Pharmacologic Treatment of Adult Patients With Major Depressive Disorder: A Clinical Practice Guideline From the American College of Physicians. Ann Intern Med. 2016 Mar 1;164(5):350-9. doi: 10.7326/M15-2570. Epub 2016 Feb 9. PubMed PMID: 26857948.
American Psychiatric Association
American Psychiatric Association. Practice Guideline for the Treatment of Patients with Major Depressive Disorder. Third edition, 2010.
British Association for Psychopharmacology
Cleare A, Pariante CM, Young AH, Anderson IM, Christmas D, Cowen PJ, Dickens C, Ferrier IN, Geddes J, Gilbody S, Haddad PM, Katona C, Lewis G, Malizia A, McAllister-Williams RH, Ramchandani P, Scott J, Taylor D, Uher R; Members of the Consensus Meeting. Evidence-based guidelines for treating depressive disorders with antidepressants: A revision of the 2008 British Association for Psychopharmacology guidelines. J Psychopharmacol. 2015 May;29(5):459-525. doi: 10.1177/0269881115581093. Epub 2015 May 12. PubMed PMID: 25969470.
Canadian Network for Mood and Anxiety Treatments (CANMAT)
Introduction and Methods
Lam RW, Kennedy SH, Parikh SV, MacQueen GM, Milev RV, Ravindran AV; CANMAT Depression Work Group. Canadian Network for Mood and Anxiety Treatments (CANMAT) 2016 Clinical Guidelines for the Management of Adults with Major Depressive Disorder: Introduction and Methods. Can J Psychiatry. 2016 Sep;61(9):506-9. doi: 10.1177/0706743716659061. Epub 2016 Aug 2. PubMed PMID: 27486152; PubMed Central PMCID: PMC4994787.
Section 1: Disease Burden and Principles of Care
Lam RW, McIntosh D, Wang J, Enns MW, Kolivakis T, Michalak EE, Sareen J, Song WY, Kennedy SH, MacQueen GM, Milev RV, Parikh SV, Ravindran AV; CANMAT Depression Work Group. Canadian Network for Mood and Anxiety Treatments (CANMAT) 2016 Clinical Guidelines for the Management of Adults with Major Depressive Disorder: Section 1. Disease Burden and Principles of Care. Can J Psychiatry. 2016 Sep;61(9):510-23. doi: 10.1177/0706743716659416. Epub 2016 Aug 2. Review. PubMed PMID: 27486151; PubMed Central PMCID: PMC4994789.
Section 2: Psychological Treatments
Parikh SV, Quilty LC, Ravitz P, Rosenbluth M, Pavlova B, Grigoriadis S, Velyvis V, Kennedy SH, Lam RW, MacQueen GM, Milev RV, Ravindran AV, Uher R; CANMAT Depression Work Group. Canadian Network for Mood and Anxiety Treatments (CANMAT) 2016 Clinical Guidelines for the Management of Adults with Major Depressive Disorder: Section 2. Psychological Treatments. Can J Psychiatry. 2016 Sep;61(9):524-39. doi: 10.1177/0706743716659418. Epub 2016 Aug 2. Review. PubMed PMID: 27486150; PubMed Central PMCID: PMC4994791.
Section 3: Pharmacological Treatments
Kennedy SH, Lam RW, McIntyre RS, Tourjman SV, Bhat V, Blier P, Hasnain M, Jollant F, Levitt AJ, MacQueen GM, McInerney SJ, McIntosh D, Milev RV, Müller DJ, Parikh SV, Pearson NL, Ravindran AV, Uher R; CANMAT Depression Work Group. Canadian Network for Mood and Anxiety Treatments (CANMAT) 2016 Clinical Guidelines for the Management of Adults with Major Depressive Disorder: Section 3. Pharmacological Treatments. Can J Psychiatry. 2016 Sep;61(9):540-60. doi: 10.1177/0706743716659417. Epub 2016 Aug 2. Review. Erratum in: Can J Psychiatry. 2017 May;62(5):356. PubMed PMID: 27486148; PubMed Central PMCID: PMC4994790.
Section 4: Neurostimulation Treatments
Milev RV, Giacobbe P, Kennedy SH, Blumberger DM, Daskalakis ZJ, Downar J, Modirrousta M, Patry S, Vila-Rodriguez F, Lam RW, MacQueen GM, Parikh SV, Ravindran AV; CANMAT Depression Work Group. Canadian Network for Mood and Anxiety Treatments (CANMAT) 2016 Clinical Guidelines for the Management of Adults with Major Depressive Disorder: Section 4. Neurostimulation Treatments. Can J Psychiatry. 2016 Sep;61(9):561-75. doi: 10.1177/0706743716660033. Epub 2016 Aug 2. Review. PubMed PMID: 27486154; PubMed Central PMCID: PMC4994792.
Section 5: Complementary and Alternative Medicine Treatments
Ravindran AV, Balneaves LG, Faulkner G, Ortiz A, McIntosh D, Morehouse RL, Ravindran L, Yatham LN, Kennedy SH, Lam RW, MacQueen GM, Milev RV, Parikh SV; CANMAT Depression Work Group. Canadian Network for Mood and Anxiety Treatments (CANMAT) 2016 Clinical Guidelines for the Management of Adults with Major Depressive Disorder: Section 5. Complementary and Alternative Medicine Treatments. Can J Psychiatry. 2016 Sep;61(9):576-87. doi: 10.1177/0706743716660290. Epub 2016 Aug 2. Review. PubMed PMID: 27486153; PubMed Central PMCID: PMC4994794.
Section 6: Special Populations
MacQueen GM, Frey BN, Ismail Z, Jaworska N, Steiner M, Lieshout RJ, Kennedy SH, Lam RW, Milev RV, Parikh SV, Ravindran AV; CANMAT Depression Work Group. Canadian Network for Mood and Anxiety Treatments (CANMAT) 2016 Clinical Guidelines for the Management of Adults with Major Depressive Disorder: Section 6. Special Populations: Youth, Women, and the Elderly. Can J Psychiatry. 2016 Sep;61(9):588-603. doi: 10.1177/0706743716659276. Epub 2016 Aug 2. Review. Erratum in: Can J Psychiatry. 2017 May;62(5):356. PubMed PMID: 27486149; PubMed Central PMCID: PMC4994788.
Commentary
Blumberger D, Conn D, Kennedy JS, Mulsant BH, Pollock BG, Rabheru K, Rapoport MJ, Seitz D. Some of the CANMAT Recommendations for the Pharmacological Treatment of Late-life Depression Are Not Congruent with Available Evidence or Expert Opinion. Can J Psychiatry. 2017 May;62(5):351-352. doi: 10.1177/0706743717700877. PubMed PMID: 28525727; PubMed Central PMCID: PMC5459232.
Racemic ketamine
Swainson J, McGirr A, Blier P, Brietzke E, Richard-Devantoy S, Ravindran N, Blier J, Beaulieu S, Frey BN, Kennedy SH, McIntyre RS, Milev RV, Parikh SV, Schaffer A, Taylor VH, Tourjman V, van Ameringen M, Yatham LN, Ravindran AV, Lam RW. The Canadian Network for Mood and Anxiety Treatments (CANMAT) Task Force Recommendations for the Use of Racemic Ketamine in Adults with Major Depressive Disorder: Recommandations Du Groupe De Travail Du Réseau Canadien Pour Les Traitements De L’humeur Et De L’anxiété (Canmat) Concernant L’utilisation De La Kétamine Racémique Chez Les Adultes Souffrant De Trouble Dépressif Majeur. Can J Psychiatry. 2020 Nov 11:706743720970860. doi: 10.1177/0706743720970860. Epub ahead of print. PMID: 33174760.
Royal Australian and New Zealand College of Psychiatrists
Malhi GS, Outhred T, Hamilton A, Boyce PM, Bryant R, Fitzgerald PB, Lyndon B, Mulder R, Murray G, Porter RJ, Singh AB, Fritz K. Royal Australian and New Zealand College of Psychiatrists clinical practice guidelines for mood disorders: major depression summary. Med J Aust. 2018 Mar 5;208(4):175-180. PubMed PMID: 29490210.
Malhi GS, Bassett D, Boyce P, Bryant R, Fitzgerald PB, Fritz K, Hopwood M, Lyndon B, Mulder R, Murray G, Porter R, Singh AB. Royal Australian and New Zealand College of Psychiatrists clinical practice guidelines for mood disorders. Aust N Z J Psychiatry. 2015 Dec;49(12):1087-206. doi: 10.1177/0004867415617657. Review. PubMed PMID: 26643054.
World Federation of Societies of Biological Psychiatry (WFSBP)
Bauer M, Pfennig A, Severus E, Whybrow PC, Angst J, Möller HJ; World Federation of Societies of Biological Psychiatry. Task Force on Unipolar Depressive Disorders. World Federation of Societies of Biological Psychiatry (WFSBP) guidelines for biological treatment of unipolar depressive disorders, part 1: update 2013 on the acute and continuation treatment of unipolar depressive disorders. World J Biol Psychiatry. 2013 Jul;14(5):334-85. doi: 10.3109/15622975.2013.804195. Epub 2013 Jul 3. PubMed PMID: 23879318. Available free HERE.
Bauer M, Severus E, Köhler S, Whybrow PC, Angst J, Möller HJ; Wfsbp Task Force on Treatment Guidelines for Unipolar Depressive Disorders. World Federation of Societies of Biological Psychiatry (WFSBP) guidelines for biological treatment of unipolar depressive disorders. part 2: maintenance treatment of major depressive disorder-update 2015. World J Biol Psychiatry. 2015 Feb;16(2):76-95. doi: 10.3109/15622975.2014.1001786. PubMed PMID: 25677972. Available free HERE.
Bauer M, Bschor T, Pfennig A, Whybrow PC, Angst J, Versiani M, Möller HJ; WFSBP Task Force on Unipolar Depressive Disorders. World Federation of Societies of Biological Psychiatry (WFSBP) Guidelines for Biological Treatment of Unipolar Depressive Disorders in Primary Care. World J Biol Psychiatry. 2007;8(2):67-104. doi: 10.1080/15622970701227829. PMID: 17455102. Available free HERE.
Related Pages
Practice guidelines in mental health: Overview
Tips on how to use practice guidelines
Practice guidelines for attention-deficit/ hyperactivity disorder (ADHD)
Practice guidelines for autism spectrum disorder
Practice guidelines for bipolar disorders
Practice guidelines for delirium
Practice guidelines for dementias
Practice guidelines for depressive disorders
Practice guidelines for eating disorders
Practice guidelines for insomnia disorder
Practice guidelines for obsessive-compulsive disorders (OCD)
Practice guidelines for posttraumatic stress disorder (PTSD)
Practice guidelines for schizophrenia
Practice guidelines for substance-related and addictive disorders
Practice guidelines for suicidality and self-harm
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