This article was first published on April 28,2017. It was last reviewed/ updated on July 28,2023. Guanfacine extended-release (Intuniv®) and clonidine extended-release (Kapvay®) are both FDA-approved for the treatment of ADHD as monotherapy or as adjunctive therapy to stimulant medications. Guanfacine extended-release (Intuniv®) and clonidine extended-release (Kapvay®) are similar in their mechanism of action and…