Factors to consider in switching from one antidepressant to another

Question from a Colleague: I want to switch my patient who has depression and pain from escitalopram 20 mg daily (which she has been taking for many years) to duloxetine. How would you advise switching? In changing (switching) from one antidepressant to another, we have to worry about two opposite things–antidepressant discontinuation symptoms and toxicity…