Combining antidepressants: Are two better than one?

We all have either tried combining antidepressants or at least inherited patients who are on a combination of antidepressants. In particular, we have heard about using an SSRI/ SNRI along with mirtazapine. The combination of venlafaxine and mirtazapine has been referred to as “California rocket fuel.” Questions: 1. Are these combinations of antidepressants really more…