Management of clozapine-induced constipation

Constipation is one of the most important potential side effects of clozapine and is the result of clozapine-induced gastrointestinal hypomotility (CIGH). Let’s start with some basic facts about it: – Constipation occurs in at least 30% of patients on clozapine,  perhaps more (Sagy et al., 2014). – Patients on clozapine are much more likely to…