Clomipramine versus SSRIs for OCD

Clomipramine is a tricyclic antidepressant that is used for the treatment of obsessive-compulsive disorder. The generic is relatively cheap while the branded Anafranil® is very expensive (about $1800 per month for 150 mg/day). On this page, we address two questions: 1. Is clomipramine more efficacious than SSRIs? 2. Can clomipramine be considered a first-line alternative to SSRIs…