Brexpiprazole: Mechanism of action

Pharmacological effects of brexpiprazole: 1. Partial agonist at the 5-HT1A, D2, and D3 receptors 2. Antagonist at 5-HT2A, 5-HT2B, 5-HT7, alpha-1 (subtypes A, B, and D), and alpha-2C receptors. Brexpiprazole versus aripiprazole What are the differences in the pharmacological activity of brexpiprazole and aripiprazole? What were the hypothesized advantages that may result from these differences? 1. Brexpiprazole has a lower…