Several studies have suggested that tricyclic antidepressants are associated with a greater risk of switching to mania or hypomania compared to other antidepressants like bupropion or SSRIs. Gijsman et al. (2004): In this meta-analysis of studies of antidepressants for bipolar depression, the rate of switching to mania or hypomania was 10% with tricyclic antidepressants and 3% for…