Cytochrome P450 drug interactions with benzodiazepines

For the benzodiazepines that are metabolized by cytochrome P450 enzymes, knowing which enzymes are responsible for metabolizing which benzodiazepine can help us in understanding drug interactions and the effect of genetic polymorphisms of the cytochrome P450 isoenzymes. Commonly used benzodiazepines (other than lorazepam, oxazepam, and temazepam) including alprazolam, chlordiazepoxide, clonazepam, and diazepam, are metabolized by CYP3A4…