This article was first published on September 17, 2024. In one clinical trial, patients whose weight was not in the overweight/ obesity category were treated with an antidepressant medication for a major depressive episode (Asmar et al., 2018). The antidepressant medications used were from all categories—selective serotonin reuptake inhibitors (SSRIs), serotonin-norepinephrine reuptake inhibitors (SNRIs), tricyclic…