Antidepressants: Dose and Duration

How much? Should we increase the dose of an SSRI after initial non-response? Here are the bottomline findings from the paper by Fava et al. (2002): 101 outpatients with major depressive disorder Either partial responders (n = 49) or non-responders (n = 52) to eight weeks of treatment with fluoxetine 20 mg/day. Randomized to four…