ABCB1 polymorphisms and psychotropic medications

What is P-glycoprotein (ABCB1 transporter)? The blood-brain barrier (BBB) is a highly evolved structure that protects the brain from the entry of potentially harmful substances. Substances that enter the brain need to pass through a layer of endothelial cells. On the luminal side (towards the blood) of this endothelial cell barrier, in the cell membrane…