FDA-indicationsOveractive bladder with symptoms of urge urinary incontinence, urgency, and urinary frequency.
Dosage and AdministrationTrospium should be taken with water on an empty stomach, at least one hour before a meal. The usual dose is 20 mg twice daily but:
- If the patient has severe renal impairment (creatinine clearance < 30 mL/min), 20 mg once daily at bedtime.
- For patients 75 years or older, the dose may be decreased to 20 mg once daily if needed.
Dosage forms and StrengthsTablets: 20 mg
Contraindications– Urinary retention – Gastric retention – Uncontrolled narrow-angle glaucoma Also, patients who are at risk for the conditions listed above. And, obviously, patients with known hypersensitivity.
Warnings and PrecautionsTrospium should be used with caution in patients with clinically significant: – Bladder outflow obstruction (due to risk of urinary retention) – Gastrointestinal obstructive disorders (due to risk of gastric retention)
Side effectsIn clinical trials, the most common side effects of troposium were: – Dry mouth 20% – Constipation 10% – Headache 4%
Important! Please refer to the full Prescribing Information (see link below) before prescribing this medication.
ReferencesSanctura® Prescribing Information. Available at https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/021595s009lbl.pdf. Accessed June 16, 2022.
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