Lisdexamfetamine (US brand name Vyvanse®) is a prodrug of dextroamphetamine that has central nervous system stimulant activity. Here is basic information about this medication.
FDA-approved indications
Attention deficit hyperactivity disorder (ADHD)
Moderate to severe binge eating disorder (BED)
Dosage
Attention deficit hyperactivity disorder (children ≥ 6 years, adults)
Initial: 30 mg every morning
Titration: 10 mg or 20 mg weekly
Recommended: 30 mg to 70 mg per day
Maximum: 70 mg per day
Binge eating disorder (adults)
Initial: 30 mg every morning
Titration: 20 mg weekly
Recommended: 50 mg to 70 mg per day
Maximum: 70 mg per day
Instructions
1. Prior to treatment, assess for presence of cardiac disease
2. Severe renal impairment: Maximum dose is 50 mg/day
3. End stage renal disease (ESRD): Maximum dose is 30 mg/day
Dosage forms and strengths
Capsules: 10 mg, 20 mg, 30 mg, 40 mg, 50 mg, 60 mg, 70 mg
Chewable tablets: 10 mg, 20 mg, 30 mg, 40 mg, 50 mg, 60 mg
Can lisdexamfetamine (Vyvanse) capsules be opened?
Yes, they can. The Prescribing Information provides the following instructions for doing that if needed.
1. Open capsules, empty and mix the entire contents (powder) with yogurt, water, or orange juice.
2. Using a spoon, break apart any powder that is stuck together.
3. Stir the powder and yogurt, water or orange juice until they are completely mixed together.
4. Consume the entire mixture immediately. It should not be stored.
5. The active ingredient dissolves completely once dispersed; however, a film containing the inactive ingredients may remain in the glass or container once the mixture is consumed.
6. Do not take anything less than one capsule per day, and a single capsule should not be divided
Savings coupons
See https://www.vyvansepro.com/savings
Please refer to Prescribing Information (see link below) for a complete discussion of dosage, administration, warnings and precautions, contraindications, etc.
Related Pages
Amphetamines
Amphetamine preparations: Index and links
Pros and cons of dextroamphetamine versus levoamphetamine.
Eight tips for reducing the risk of abuse/diversion of stimulants
Ketogenic diet and amphetamines
Vitamin C if on a stimulant?
Does lisdexamfetamine really have lower abuse potential?
Converting from OROS methylphenidate to amphetamine is a two-step process
Amphetamine (Dynavel-XR®) extended-release oral suspension: Basic information
Amphetamine extended-release orally disintegrating tablets (Adzenys XR-ODT): Basic information
What is the maximum dose of mixed amphetamine salts?
Do psychostimulant medications cause clinically-significant increases in blood pressure?
How exactly should blood pressure be monitored in persons on stimulants
How to manage stimulant-induced hypertension
Dextroamphetamine (Dexedrine®): Basic Information
Lisdexamfetamine (Vyvanse®): Basic Information
Mixed amphetamine salts (Adderall®, Adderall XR®): Basic Information
Mixed salts of a single-entity amphetamine product (Mydayis®): Basic information
Triple-bead preparation of mixed amphetamine salts (Mydayis®)
References
Lisdexamfetamine Prescribing Information
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