Armodafinil (US brand name Nuvigil®) is a wakefulness-promoting agent.
On this page, we will provide basic information about this medication. Links to other articles on this website with more advanced information and tips related to this medication and related topics are provided below, under the “Related Pages” section.
FDA-approved indications
To improve wakefulness in adult patients with excessive sleepiness associated with obstructive sleep apnea, narcolepsy, or shift work disorder
Dosage
1. Adults
Narcolepsy or OSA: 150 mg to 250 mg once daily in the morning
Shift work disorder: 150 mg once a day taken approximately one hour prior to the start of the work shift
2. Geriatric patients
Consider lower doses
3. Patients with severe hepatic impairment
Dosage should be reduced
Drug interactions caused by armodafinil (Nuvigil®)
Induces CYP3A4/5. Therefore, may reduce levels of steroidal contraceptives, cyclosporine, midazolam, triazolam, etc.
Inhibits CYP2C19. Therefore, may increase levels of phenytoin, diazepam, propranolol, omeprazole, clomipramine, etc.
When armodafinil is used with warfarin, PT/ INR should be monitored more frequently.
Armodafinil should be used with MAO inhibitors only with great caution.
Dosage forms and strengths
Tablets: 50 mg, 150 mg, 200 mg, and 250 mg
Please refer to Prescribing Information (see link below) for a complete discussion of dosage, administration, warnings and precautions, contraindications, etc.
Related Pages
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Modafinil as an adjunct for major depressive disorder?
Do modafinil/ armodafinil need cardiovascular monitoring
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Solriamfetol
Solriamfetol (Sunosi®): Basic Information
Obstructive Sleep Apnea Hypopnea—Screening
Obstructive sleep apnea is common and massively underdiagnosed
Are we missing the diagnosis of obstructive sleep apnea hypopnea (OSAH) in our patients with major depressive disorder?
STOP-Bang Questionnaire
How to screen for sleep apnea
How to know if our patients snore—even if they live alone
Epworth Sleepiness Scale (my brief summary and link to the scale itself)
How to measure neck circumference
Obstructive Sleep Apnea Hypopnea—Sleep studies
In a sleep study result, what is the Respiratory Disturbance (Distress) Index (RDI)?
Apnea-Hypopnea Index
What does the respiratory event index (REI) on a home sleep study mean?
Obstructive Sleep Apnea Hypopnea—Management
Clinical tips on excessive daytime sleepiness (hypersomnolence)
Tirzepatide (Zepbound®) for obstructive sleep apnea (OSA)
Which hypnotics to use or avoid in persons with sleep apnea
Are dual orexin receptor antagonists (DORAs) safe in obstructive sleep apnea?
References
Prescribing Information for Armodafinil (Nuvigil®). Available at this link.
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