Vortioxetine versus other antidepressants

Vortioxetine (brand name Trintellix in the US) was approved in 2013 by the United States FDA for the treatment of major depressive disorder. A key question for clinicians: Is vortioxetine either more efficacious than other antidepressants (e.g., SSRIs, SNRIs) for the treatment of major depressive disorder or does it have a better side effect profile than they do?…