Serotonin receptor 2A (5-HT2A) polymorphisms and adverse effects

Postsynaptic 5-HT2A receptors are widely distributed in both the central nervous system and elsewhere in the body. Activation of these receptors can affect: – Sleep and arousal – Sexual behavior – Gut motility – Vascular smooth muscle tone Therefore, one might expect that some side effects of serotonergic antidepressants like insomnia, agitation, gastrointestinal distress, and sexual dysfunction may…