1. SSRI that is a significant inhibitor of cytochrome P450 2D6 only at a higher dose Sertraline. Up to 100 mg/day, sertraline only mildly inhibits the 2D6 isoenzyme. However, above 150 mg/day sertraline is a significant, moderate or potent inhibitor of 2D6. It is important to remember that fluoxetine and paroxetine are potent inhibitors of…