When the basic (Level 1) strategies (discussed on another page on this website) don’t work, what should we do next? 5-HT3 antagonists What about the “Setrons,” i.e., ondansetron, granisetron, etc.? These medications have been extensively used for the treatment of nausea/vomiting in various medical conditions, including chemotherapy-induced nausea. Nausea associated with SSRIs and SNRIs is…