What is the mechanism of action of lurasidone? Similar to other second-generation antipsychotics, lurasidone is a: 1. Potent D2 antagonist (responsible for the antipsychotic effect) 2. Potent 5HT2a antagonist (responsible for the antipsychotic effect and reduces incidence of parkinsonism with the second-generation antipsychotics) Lurasidone is also a: 3. Potent serotonin 1 A (5HT-1A) receptor partial…