L-methylfolate can sometimes precipitate irritability, agitation, insomnia, or aggressiveness

L-methylfolate (brand name Deplin® and various generics) is sometimes added to antidepressant medications after an inadequate response to the antidepressant alone. For more on this, please see the following article on this website: What you need to know about L-methylfolate (Deplin®) On this page, I am not discussing whether L-methylfolate works and, if so, in…