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Did recent studies find that lithium may not work for bipolar depression?

I was surprised to read in an important review article on bipolar II disorder the following statements (emphasis in red added by us; Berk et al., 2025): “Lithium, traditionally used as monotherapy or in combination with other pharmacotherapies, has long been a staple in the treatment of BD-­ II depression (Vieta and Valentí, 2013). However,…

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