On other pages on this website, we have discussed antidepressant-induced hyponatremia. Please see Related Pages below. If the same serotonin reuptake inhibitor is restarted after the hyponatremia resolves (i.e, rechallenge) the hyponatremia may or may not recur. Some patients seem to be predisposed to developing antidepressant-induced hyponatremia and develop it again with the next antidepressant…