Cyproheptadine (Periactin®) for antidepressant-induced sexual dysfunction (ADISD)?

While antidepressant-induced erectile dysfunction (ADISD) can be treated with PDE-5 inhibitors like sildenafil, tadalafil, etc., but decreased libido, delayed or absent ejaculation in men, and anorgasmia in women are harder to treat. On this page, we will discuss the potential use of cyproheptadine (brand name Periactin) as a potential treatment for these sexual adverse effects…