Add aripiprazole to treat clozapine-induced weight gain?

Question from a Member: Our Member asked about a patient who has a marked increase in appetite and weight on clozapine. Metformin and topiramate were not tolerated. Numerous attempts were made to switch him to other antipsychotics or to decrease his clozapine dose, but his psychotic symptoms would worsen. Clozapine is an invaluable treatment for…