Are MAO inhibitors (MAOIs) efficacious and safe for bipolar depression?

By Rajnish Mago, MD (bio) Bipolar depression is an important, disabling condition, associated with a significant risk of suicide. And, it is hard to treat. So, more options for “difficult-to-treat” bipolar depression are sorely needed. Is tranylcypromine one of the third line options? What do practice guidelines say? Tranylcypromine is recommended as a third-line option…