How and why to compare antipsychotics’ affinity for alpha-1 receptors

How to compare affinity for alpha-1 adrenergic receptors One commonly used measure of the affinity (strength) with which a drug binds to a particular type (or subtype) of receptor is its Ki or inhibitory constant (also called the inhibition constant). In plain English, the Ki represents the concentration of the drug (in nanomoles or nM) required to occupy 50% of those receptors. For example,…