Will patients regain weight after GLP-1 receptor agonists are stopped?

Glucagon-like peptide-1 (GLP-1) receptor agonists like semaglutide (Wegovy®) and tirzepatide (Zepbound®) are highly effective treatments for obesity and overweight in patients with or without diabetes. Even though these medications don’t have a specific FDA indication for the treatment of medication-induced weight gain, they are being used off-label for this purpose. Several of my patients have…