Lithium-induced renal impairment: Clinical recommendations

Question from a Member: I have a 43-year-old male with bipolar disorder. He is stable on a combination of lamotrigine and lithium 1200 mg daily with a level of 0.75. He now presents with [an estimated] GFR of 72 and, so, Stage 2 kidney disease. Is it imperative that I wean him off the lithium?…