Combining an MAO inhibitor and another antidepressant

Combining an MAO inhibitor and trazodone or a TCA Trazodone was used in a case series of 13 patients (Nierenberg and Keck, 1989). Also, in an uncontrolled study (Jacobsen, 1990), 20 of 21 patients with MAOI-induced insomnia improved after the addition of 50 to 75 of trazodone. Combining an MAO inhibitor and a tricyclic antidepressant…