Are these statements TRUE or FALSE?
Though the links to the relevant articles are provided, you DON’T have to re-read that article. Correct answers are given in just one or two sentences.
1. Due to a concern about possible QT prolongation, the maximum daily dose of hydroxyzine should not exceed 100 mg per day.
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Answer: True
Explanation: Even though the maximum dose of hydroxyzine recommended by the FDA is 400 mg/day, in 2015 the European Medicines Agency recommended that the dose of hydroxyzine should not exceed 100 mg/day in adults and 50 mg/day in the elderly.
Review: Hydroxyzine (Vistaril®, Atarax)
2. In patients on dialysis, the dose of medications that are highly protein bound may need to be significantly reduced because they medication will get dialyzed along with the protein.
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Answer: False
Explanation: For patients on dialysis, drugs that are highly protein bound, like SSRIs, are not a concern because they will not get dialyzed. The proteins are too big to be filtered by the kidney.
3. If antidepressant-induced sexual dysfunction appears, we should encourage the patient to first wait-and-watch because there is about a 50% chance that the sexual dysfunction will subside on its own without doing anything.
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Answer: False
Explanation: Unfortunately, antidepressant-induced sexual dysfunction subsides in only 10% of cases. It may show partial improvement in another 10% of patients.
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