It is a sad fact that some persons with major depressive disorder fail to respond to all available treatments. Clinicians are then forced to use unproven strategies based on clinical experience and/or published case reports. References Koola MM, Fawcett J. Dextroamphetamine and Pramipexole Combination for Treatment-Resistant Unipolar Depression. Psychiatr Ann. 2016 Aug;46(8):429-431. PubMed PMID: 27667864;…