What is S-adenosylmethionine or SAMe? SAMe is a compound that is present throughout the brain (and in many other parts of the body). It is an important methyl donor and is involved in hundreds of metabolic processes including the production (and repair) of DNA, proteins, phospholipids, and–of interest to mental health professionals–monoamine neurotransmitters (serotonin, norepinephrine, and…