Ramelteon (Rozerem® and generic) is a melatonin receptor agonist that is used as a hypnotic. Here is basic information about this medication.
Treatment of insomnia characterized by difficulty with sleep onset
Comapared to melatonin, ramelteon has six times more affinity for melatonin receptors 1 (MT1) and three times more affinity for melatonin receptors 2 (MT2; Miyamoto, 2009).
Adults: 8 mg taken within 30 minutes of going to bed
a) Do not take with or after a high-fat meal
b) Do not exceed 8 mg/day
Dosage forms and strengths
Tablet: 8 mg
Please refer to Prescribing Information (see link below) for complete discussion of dosage, administration, warnings and precautions, contraindications, etc.
Miyamoto M. Pharmacology of ramelteon, a selective MT1/MT2 receptor agonist: a novel therapeutic drug for sleep disorders. CNS Neurosci Ther. 2009 Winter;15(1):32-51. Review. PubMed PMID: 19228178; PubMed Central PMCID: PMC2871175.
Last revised January 2019
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