How much better is olanzapine-samidorphan (Lybalvi®) than olanzapine alone?

The combination of olanzapine and samidorphan (an opioid antagonist) is available in the United States under the brand name Lybalvi®. Combining samidorphan with olanzapine has been shown to reduce weight gain compared to treatment with olanzapine alone. It makes no difference either way to the efficacy of the medication. For Basic Information about the olanzapine-samidorphan…