THIS PAGE IS UNDER CONSTRUCTION
Why do we need non-stimulant options?
There are many reasons why we need non-stimulant options for treating ADHD in adults.
1. Stimulants don’t work in all patients
2. Some patients may need another treatment to be added to a stimulant because of incomplete response
3. In some patients, comorbid illnesses like bipolar disorder, may suggest that we should first use an alternative treatment.
4. Comorbidity may be present that may make us prefer alternative medications in order to treat both disorders with the same medication (e.g., depressive disorders, anxiety disorders)
5. Some patients may not be able to tolerate stimulants
6. Some patients may be an increased risk of abuse or diversion of stimulants
What are our pharmacological options?
FDA-approved
Atomoxetine is the only FDA-approved non-stimulant for ADHD as of July 2017.
Supported by at least two randomized, controlled clinical trials by at least two different research groups
Bupropion
Supported by at least one randomized, controlled clinical trial
Desipramine
Other
Modafinil?
Other antidepressants (venlafaxine, paroxetine, nomifensine, reboxetine, duloxetine)
Related Pages
References
Buoli M, Serati M, Cahn W. Alternative pharmacological strategies for adult ADHD treatment: a systematic review. Expert Rev Neurother. 2016;16(2):131-44. Review. PubMed PMID: 26693882.
Spencer T, Biederman J, Wilens T. Nonstimulant treatment of adult attention-deficit/hyperactivity disorder. Psychiatr Clin North Am. 2004 Jun;27(2):373-83. Review. PubMed PMID: 15064003.
Copyright © 2017, Rajnish Mago, MD. All rights reserved. May not be reproduced in any form without express written permission.
Disclaimer: The content on this website is provided as general education for medical professionals. It is not intended or recommended for patients or other lay persons or as a substitute for medical advice, diagnosis, or treatment. Patients must always consult a qualified health care professional regarding their diagnosis and treatment. Healthcare professionals should always check this website for the most recently updated information.