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Acute bipolar depression is notoriously hard to treat. We are often in the situation where the person is on a mood stabilizer like lithium or divalproex with partial benefit but has
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References
Alamo C, López-Muñoz F, García-García P. The effectiveness of lurasidone as an adjunct to lithium or divalproex in the treatment of bipolar disorder. Expert Rev Neurother. 2014 Jun;14(6):593-605. Review. PubMed PMID: 24779382.
Loebel A, Cucchiaro J, Silva R, Kroger H, Sarma K, Xu J, Calabrese JR. Lurasidone as adjunctive therapy with lithium or valproate for the treatment of bipolar I depression: a randomized, double-blind, placebo-controlled study. Am J Psychiatry. 2014 Feb;171(2):169-77. PubMed PMID: 24170221.
Suppes T, Kroger H, Pikalov A, Loebel A. Lurasidone adjunctive with lithium or valproate for bipolar depression: A placebo-controlled trial utilizing prospective and retrospective enrollment cohorts. J Psychiatr Res. 2016 Jul;78:86-93. PubMed PMID: 27089521.
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