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In persons with renal failure, the half-life of lamotrigine may be slightly increased from a mean of about 28 hours to a mean of 36 hours (Wooton et al., 1997).
Related Pages
Stages of kidney disease
Lamotrigine (Lamictal®): Basic Information
References
Fillastre JP, Taburet AM, Fialaire A, Etienne I, Bidault R, Singlas E. Pharmacokinetics of lamotrigine in patients with renal impairment: influence of haemodialysis. Drugs Exp Clin Res. 1993;19(1):25-32. PubMed PMID: 8223137.
Kaufman KR. Lamotrigine and hemodialysis in bipolar disorder: case analysis of dosing strategy with literature review. Bipolar Disord. 2010 Jun;12(4):446-9. PubMed PMID: 20636643.
Smetana KS, Cook AM, Bastin ML, Oyler DR. Antiepileptic dosing for critically ill adult patients receiving renal replacement therapy. J Crit Care. 2016 Dec;36:116-124. Review. PubMed PMID: 27546759.
Wootton R, Soul-Lawton J, Rolan PE, Sheung CT, Cooper JD, Posner J. Comparison
of the pharmacokinetics of lamotrigine in patients with chronic renal failure and healthy volunteers. Br J Clin Pharmacol. 1997 Jan;43(1):23-7. PubMed PMID: 9056048.
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