THIS PAGE IS UNDER CONSTRUCTION Mechanism of action Guanfacine is not a central nervous system (CNS) stimulant. It is a selective agonist of alpha 2A-adrenergic receptors. Stimulation of post-synaptic α2A-adrenergic receptors is believed to increase noradrenergic neurotransmission. Guanfacine has been shown to improve prefrontal cortical cognitive function (including working memory; Huss et al., 2016). What…